abstract：AIM:To analyze female gender as a possible age-dependent prognostic factor for overall (OS) and cancer-specific survival (CSS) in patients with upper urinary tract urothelial carcinoma (UUTUC) after radical nephroureterectomy (RNU). PATIENTS AND METHODS:A total of 167 men and 101 women with UUTUC treated with RNU with...

journal_title：Anticancer research

authors： Sikic D,Wach S,Taubert H,Richterstetter M,Kunath F,Goebell PJ,Schick S,Olbert P,Huber J,Wullich B,Keck B

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIM:Novel treatment strategies aiming to eliminate or attenuate the invasive phenotype of glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, could offer a profound therapeutic benefit to patients. We previously demonstrated one method to create invasive sub-populations of GBM ...

journal_title：Anticancer research

authors： Koo S,Martin G,Toussaint LG

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND/AIM:The success of proteasome inhibitors in therapy of multiple myeloma has led to their use for other malignancies. For the proteasome inhibitor bortezomib, combination therapies with histone deacetylase inhibitors, which up-regulate ubiquitin-proteasome system (UPS)-related enzymes, produce a beneficial ef...

journal_title：Anticancer research

authors： Takenokuchi M,Miyamoto K,Saigo K,Taniguchi T

更新日期：2015-06-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the impact of cyclin E expression on cancer-specific survival, as well as on conventional clinocopathological and prognostic factors in endometrial endometrioid adenocarcinoma. MATERIALS AND METHODS:The study consisted of 211 patients surgically treated for endometri...

journal_title：Anticancer research

authors： Santala S,Talvensaari-Mattila A,Soini Y,Santala M

更新日期：2015-06-01 00:00:00

abstract：AIM:To retrospectively compare the efficacy of two irinotecan-based chemotherapy regimens combined with bevacizumab in first-line therapy of metastatic colorectal cancer (mCRC). PATIENTS AND METHODS:The data of 558 patients with mCRC treated with first-line bevacizumab plus irinotecan-containing regimen were obtained ...

journal_title：Anticancer research

authors： Kocakova I,Melichar B,Kocak I,Bortlicek Z,Büchler T,Dusek L,Petruzelka L,Kohoutek M,Prausová J,Finek J,Mohelnikova-Duchonova B,Vyzula R

更新日期：2015-06-01 00:00:00

abstract：:We describe a very rare case of recurrent hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT). A 47-year-old female underwent LDLT for HCC within Milan criteria, receiving a left liver lobe from her 38-year-old husband with an incompatible blood type. Thirty months after LDLT, however, enhan...

journal_title：Anticancer research

authors： Shimokawa M,Itoh S,Ikegami T,Takeishi K,Harimoto N,Yamashita YI,Yoshizumi T,Kawanaka H,Shirabe K,Maehara Y

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND/AIM:Lymphatic invasion (ly) may mainly reflect the selective affinity of breast cancer cells for lymph nodes. We conducted the present study to investigate whether the presence of lymphatic invasion is a predictor of sentinel lymph node (SLN) metastasis in clinically node-negative breast cancer. PATIENTS AN...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tatsuki H,Suto T,Morita H,Tsutsumi S,Kuwano H

更新日期：2015-06-01 00:00:00

abstract：:Radiation therapy is essential for local tumor control for many types of cancer histologies. Technological advancements in recent years have allowed for precise irradiation of target tissues while minimizing the dose to non-target tissues. To enhance radiation damage to cancer cells and further limit the radiation eff...

journal_title：Anticancer research

authors： Linam J,Yang LX

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:Combretastatin A-4 phosphate (CA4P) is a vascular-disrupting agent which affects the level of circulating neutrophils. Since tumor-associated macrophages and neutrophils may collaborate, we compared the effect of CA4P treatment on monocytes/macrophages and neutrophils. MATERIAL AND METHODS:CDF1 mice wit...

journal_title：Anticancer research

authors： Bohn AB,Brems-Eskildsen AS,Møller BK,Horsman MR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is critical in inflammation, proliferation and carcinogenesis. There exist three main players in this pathway. The inhibitor of NF-κB (IκB), IκB kinase (IκK)- NF-κB essential modulator (NEMO) complex and NF-κB. The IkK-NEMO co...

journal_title：Anticancer research

authors： Kadioglu O,Nass J,Saeed ME,Schuler B,Efferth T

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:Kallikrein-related peptidases (KLKs) comprise a serine protease family with prominent roles in tissue physiology and disease pathogenesis, including cancer. Previously, we have characterized canine Klk4-10 and -14. Herein, we continue our efforts by characterizing three novel members of the canine family...

journal_title：Anticancer research

authors： Angelopoulou K,Karagiannis GS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Canine lymphoma has lately drawn focus as a model of human non-Hodgkin's lymphoma due to its spontaneous occurrence and similar biological behavior. Cells with stem cell-like characteristics are believed to play a key role in therapeutic failure. Thus, an initial characterization and the possibility of speci...

journal_title：Anticancer research

authors： Liu W,Selçuk F,Rütgen BC,Moulay M,Willenbrock S,Hammer SE,Sterenczak KA,Junghanss C,Hewicker-Trautwein M,Nolte I,Murua Escobar H

更新日期：2015-05-01 00:00:00

abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...

journal_title：Anticancer research

authors： Vasilyev S,Smirnova E,Popov D,Semenov A,Eklund C,Hendolin P,Paloheimo L,Syrjänen K

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-32 (IL32) has been newly-identified as a proinflammatory cytokine. In the present study, we aimed to clarify the clinical role of IL32-positive cells in esophageal squamous cell cancer (ESCC) and regulatory T-cell (Treg) infiltration in the stroma. A total of 179 patients with ESCC who underw...

journal_title：Anticancer research

authors： Nabeki B,Ishigami S,Uchikado Y,Sasaki K,Kita Y,Okumura H,Arigami T,Kijima Y,Kurahara H,Maemura K,Natsugoe S

更新日期：2015-05-01 00:00:00

abstract：:Serum levels of thymidine kinase 1 (TK1), an enzyme involved in the G1-S phase of the cell cycle, have been previously shown to correlate with the prognosis of lymphoid malignancies. We hypothesized that TK1 levels will be higher in aggressive, compared to indolent lymphoproliferative, malignancies and this may serve ...

journal_title：Anticancer research

authors： Gatt ME,Goldschmidt N,Kalichman I,Friedman M,Arronson AC,Barak V

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Primary small cell carcinoma of the ovary (SCCO) is rare, making prognosis and outcomes largely undefined. PATIENTS AND METHODS:Using case listing session of SEER 18 (1973-2010), we examined outcomes for patients with SCCO. Analyses were conducted with SEER(*)Stat 8.1.2, Microsoft Excel 2007 and GraphPad Pr...

journal_title：Anticancer research

authors： Jamy O,Yaghmour G,Hare F,Martin MG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to investigate how oxidative status influences the effectiveness of cytotoxicity of artemisinin towards cancer cells. It is hypothesized that antioxidants would reduce, whereas pro-oxidants would enhance, cytotoxicity. MATERIALS AND METHODS:Molt-4 human leukemia cells ...

journal_title：Anticancer research

authors： Gerhardt T,Jones R,Park J,Lu R,Chan HW,Fang Q,Singh N,Lai H

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Hyperbaric oxygen (HBO) seems to intensify the effect of ionising radiation. We investigated whether HBO combined with irradiation decreases the capability of U251 glioblastoma cells for relapse and metastasis. MATERIALS AND METHODS:Cells were treated with O2 at 1.3 bar and then irradiated with 2 Gy photons...

journal_title：Anticancer research

authors： Bühler H,Strohm GL,Nguemgo-Kouam P,Lamm H,Fakhrian K,Adamietz IA

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small non-coding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation...

journal_title：Anticancer research

authors： Reddemann K,Gola D,Schillert A,Knief J,Kuempers C,Ribbat-Idel J,Ber S,Schemme J,Bernard V,Gebauer N,Feller AC,Thorns C

更新日期：2015-04-01 00:00:00

abstract：AIM:Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. PATIENTS AND METHODS:Forty-nine patients with early-...

journal_title：Anticancer research

authors： Tuohinen SS,Skyttä T,Virtanen V,Luukkaala T,Kellokumpu-Lehtinen PL,Raatikainen P

更新日期：2015-04-01 00:00:00

abstract：AIM:Metabolic syndrome has been identified as a risk factor for colorectal cancer and adenoma. The aim of our study was to assess the risk of colorectal cancer and adenoma in an adult Italian population with metabolic syndrome. PATIENTS AND METHODS:Ninety patients with metabolic syndrome were prospectively compared ag...

journal_title：Anticancer research

authors： Fiori E,Lamazza A,De Masi E,Schillaci A,Crocetti D,Antoniozzi A,Sterpetti AV,De Toma G

更新日期：2015-04-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in cancer cells; however, the clinical implication of their expression remains unknown. A total of 209 patients with gastric cancer were enrolled in this study. Immu...

journal_title：Anticancer research

authors： Ishigami S,Arigami T,Okumura H,Uchikado Y,Kita Y,Kurahara H,Maemura K,Kijima Y,Ishihara Y,Sasaki K,Uenosono Y,Natsugoe S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIM:Diffusion-weighted imaging (DWI) allows for differentiation of benign from malignant tumors, histological tumor types and their grade. The aim of the study was to evaluate the capabilities of DWI using 3 Tesla Magnetic resonance imaging (3T MRI) in the preoperative assessment of renal tumors. PATIENTS A...

journal_title：Anticancer research

authors： Mirka H,Korcakova E,Kastner J,Hora M,Hes O,Hosek P,Ferda J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to share...

journal_title：Anticancer research

authors： Mahmood S,Vu K,Tai P,Joseph K,Koul R,Dubey A,Yu E

更新日期：2015-04-01 00:00:00

abstract：:Fine needle aspiration (FNA) cytology, being the mainstay to diagnose thyroid nodules, does not provide definitive results in a subset of patients. The use of molecular markers testing has been described as a useful aid in differentiation of thyroid nodules that present with an indeterminate cytodiagnosis. Molecular t...

journal_title：Anticancer research

authors： Bhatia P,Deniwar A,Friedlander P,Aslam R,Kandil E

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Live animal studies using an inoculation model of breast cancer indicate that anaesthetic drugs and techniques differentially affect cancer metastasis, inversely related to Natural Killer (NK) cell and T lymphocyte levels. Clinical histological studies demonstrate that the distribution of these immune cells ...

journal_title：Anticancer research

authors： Desmond F,McCormack J,Mulligan N,Stokes M,Buggy DJ

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-t...

journal_title：Anticancer research

authors： Aderhold C,Faber A,Umbreit C,Chakraborty A,Bockmayer A,Birk R,Sommer JU,Hörmann K,Schultz JD

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:The role of methylation reactions in cancer was examined using the methylating agents, sulfobetaine [dimethylsulfonioproponate (DMSP)], and glycine betaine (GB), in murine crucial Ehrlich ascites carcinoma (EAC) for up to 10 days. RESULTS:DMSP administration in EAC-bearing mice mitigated EAC, while GB a...

journal_title：Anticancer research

authors： Nakajima K,Nakajima Y,Tsujiwaki S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:Several studies have revealed an association between single nucleotide polymorphisms (SNPs) in the VDR gene and prostate cancer (PCa) risk in European and Asian populations. To investigate whether VDR SNPs are associated with PCa risk in African-American (AA) men, nine VDR SNPs were analyzed in a case-co...

journal_title：Anticancer research

authors： Jingwi EY,Abbas M,Ricks-Santi L,Winchester D,Beyene D,Day A,Naab TJ,Kassim OO,Dunston GM,Copeland RL Jr,Kanaan YM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:The associations between emotional personality, proximity and authenticity in patient-physician communication during breast cancer (BC) consultations are rarely considered together in a prospective study. We, therefore, investigated emotional personality/proximity versus authenticity in patient-physician...

journal_title：Anticancer research

authors： Eskelinen M,Korhonen R,Selander T,Ollonen P

更新日期：2015-03-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the efficacy and tolerability of vinorelbine and cisplatin for the treatment of patients with advanced (stage IIIB, IV or relapse) non-small cell lung cancer (NSCLC) with interstitial pneumonia (IP). PATIENTS AND METHODS:A total of 67 patients treated with vinorelbin...

journal_title：Anticancer research

authors： Watanabe N,Niho S,Kirita K,Umemura S,Matsumoto S,Yoh K,Ohmatsu H,Goto K

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:We undertook a case-control and a case-case study to examine the possible association of p53 codon72 polymorphism with the breast cancer risk and resistance to anthracycline-based chemotherapy. PATIENTS AND METHODS:Case-control study: This study enrolled 175 patients with breast cancer treated at the Sa...

journal_title：Anticancer research

authors： Arfaoui A,Douik H,Kablouti G,Chaaben AB,Handiri N,Zid Z,Ouni N,Zouiouch F,Ayari F,Mamoughli T,Bouassida J,Abazza H,Harzallaha L,Guemira F

更新日期：2015-03-01 00:00:00

abstract：:Although cancer belongs to one of the leading causes of death around the world, fortunately studies have shown that tumor cells have various targets that are susceptible to attack. Interestingly, tumor cells are comprised of cellular membranes, which are altered in chemical composition relative to non-neoplastic cells...

journal_title：Anticancer research

authors： Oelkrug C,Hartke M,Schubert A

更新日期：2015-02-01 00:00:00

abstract：AIM:To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS:We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS:Three months after injection o...

journal_title：Anticancer research

authors： Den Otter W,Hack M,Jacobs JJ,Tan JF,Rozendaal L,Van Moorselaar RJ

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that disproportionately affects women with darker skin. Epidemiological studies indicate that higher vitamin D levels prevent incidence of TNBC and translate to higher survival rates in those that have TNBC. MATERIALS AND METHODS:Th...

journal_title：Anticancer research

authors： Richards SE,Weierstahl KA,Kelts JL

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/AIM:Accumulating evidence shows that various types of cancers induce a specific immune response resulting in the production of antibodies against self-components (autoantibodies). The aim of the present study was to identify antigens for autoantibodies in sera from patients with ovarian cancer, especially cl...

journal_title：Anticancer research

authors： Yoneyama K,Kojima S,Kodani Y,Yamaguchi N,Igarashi A,Kurose K,Kawase R,Takeshita T,Hattori S,Nagata K

更新日期：2015-02-01 00:00:00

abstract：AIM:To evaluate the proliferation activity in gliomas using 18F-fluorothymidine (18F-FLT)-positron emission tomography/computed tomography (PET/CT). PATIENTS AND METHODS:Samples of 26 tumors were analyzed (mean age=51.6; range=26-72 years; 16 males, 10 females). All examinations were performed using a PET/CT scanner e...

journal_title：Anticancer research

authors： Ferdová E,Ferda J,Baxa J,Tupý R,Mraček J,Topolčan O,Hes O

更新日期：2015-02-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We defined CNS-collapse as de...

journal_title：Anticancer research

authors： Hata A,Katakami N,Yoshioka H,Takeshita J,Tanaka K,Masago K,Fujita S,Kaji R,Imai Y,Monden K,Matsumoto T,Nagata K,Otsuka K,Tachikawa R,Tomii K,Kunimasa K,Iwasaku M,Nishiyama A,Ishida T,Nishimura Y

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/AIM:Recent progress with BRAF and immune checkpoint inhibitors has dramatically changed the treatment landscape of metastatic melanoma (MM). The limited duration of responses to new agents, however, justifies the, still important, role of chemotherapy in the management of MM. This study prospectively explore...

journal_title：Anticancer research

authors： Linardou H,Pentheroudakis G,Varthalitis I,Gogas H,Pectasides D,Makatsoris T,Fountzilas G,Bafaloukos D,Hellenic Cooperative Oncology Group.

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Vitamin D is known for its anti-cancerogenous potential. Prostaglandin E2 (PGE2) is a proliferation and inflammation activating agent. The production of PGE2 is dependent on the activity of cyclooxygenase-2 (COX-2). A link between vitamin D and PGE2 metabolism was recently shown. MATERIALS AND METHODS:In MD...

journal_title：Anticancer research

authors： Thill M,Reichert K,Woeste A,Polack S,Fischer D,Hoellen F,Rody A,Friedrich M,Köster F

更新日期：2015-02-01 00:00:00